Surface Charge Density Driven Delivery of Drugs and Plasmid DNA to Skin Using Atmospheric Ion Sources

摘要

Low energy ion deposition to create electric fields in tissue provides an attractive means to electrically'mediate and induce delivery of normally non-permeant molecules to tissue cells in vivo. Electrically mediated therapies have progressed to clinical demonstration yet require anesthetic to minimize patient discomfort. Ions generated at atmospheric pressure may be applied to the skin surface to produce an electric field in the tissue leading to an effective delivery of molecules to cells. Such processes are charge limited and therefore do not produce high current in the tissue.