β-Substituted D-Leucines and Their Relevance in the Total Synthesis of Natural and Unnatural Aeruginosins

摘要

Methods for the synthesis of diastereomerically pure β-chloro and β-methyl-D-leucines and their derivatives are described. The incorporation of these residues in natural and non-natural analogues is shown with relevance to their in vitro thrombin inhibitory activities.