THE SYNTHESIS OF POLY(5-ACRYLOYLAMINOSALICYLIC ACID)AS POLYMER DRUGS

摘要

5-Aminosalicylic acid (5-ASA) is a drug used in the treatment of Crohn's disease and ulcer at ive colitis. It is very unstable. In order to control the stability of 5-ASA. Patricia C. Wang etc prepared a series of polymeric compounds linking 5-ASA to the polymeric carriers via aromatic azo bonds. These azo links can be cleaved by ba-teria in the mammaliam lower bowel, thereby releasing 5-ASA.