Automatic Optimal-Adaptive Control of Brain Temperature by Water-Cooling System

摘要

Automatic control system of brain tissue temperature ( BTT) is synthesized to replace its conventional manual regulation system for brain hypothermia treatment (BHT). In order to verify the optimal-adaptive control mechanism previously proposed by the authors, a mechanical automatic temperature regulation system is constructed to simulate the clinic BHT, by introducing a mannequin model with possible characteristic change instead of the patients in ICU. Electric heater and heat exchanger are used to regulate the water temperature circulating in the cooling blanket according to the optimal-adaptive control mechanism. The representative temperature of the mannequin's head (hereafter, brain temperature) is successfully realized to follow up the desired temperature course automatically. The adaptive control of the mannequin's brain temperature with the optimal control of the cooling blanket is verified from the various kinds of simulation experiments. Then, the proposed combinatory control mechanism is confirmed valid and available for the clinical application to BHT.