Main Pathway Discovery in Metabolic Pathways

摘要

The requires an integrative biological systems analysis as the quantitative description at the hierarchical level of molecular, cellular and phenotypic functions including their interaction with the environment is very complex. The growing awareness of the complex interplay between the genome and physiological functions of the cell needs a new holistic and full integrative view. Our goal is to give a better comprehension of the physiological state of the cell from a better interpretation of the interactions between metabolic and signaling networks. In this paper a logical model of Glycolysis is proposed allowing to describe the dynamical response of a biological system perturbed by a pulse of glucose. Starting with the discretization of some metabolite considered in steady state hypothese finding produce logical formulas on the metabolites which cannot be measured in a dynamical states and therefore the main pathway.