Clinical and Material Performance of Conventional, EtO-Sterilized Tibial Components

摘要

In the 1990's, concerns arose about oxidation of ultra-high molecular weight polyethylene (UHMWPE) components due to free radicals formed during gamma sterilization. In response, a low oxygen sterilization environment was used; however, this may just delay the oxidation process until the components are removed from the packaging [1]. Another option manufacturers pursued was ethylene oxide (EtO) sterilization. Because EtO does not produce free radicals, it is expected that these implants will not oxidize. However, EtO-sterilized inserts do not benefit from wear reduction associated with radiation crosslinking, so the risk of osteolysis remains a concern. We tested the hypothesis that EtO sterilized inserts would exhibit resistance to in vivo oxidation and osteolysis.