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首页> 外文会议>23rd European conference on biomaterials 2010 >Photocrosslinked poly(ester anhydride) for controlled delivery of peptide YY_(3.36)
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Photocrosslinked poly(ester anhydride) for controlled delivery of peptide YY_(3.36)

机译：光交联的聚（酯酐），用于控制释放肽YY_（3.36）

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摘要

Poly(ester anhydrides) have been developed in order to combine advantageous properties of two well-characterized biocompatible materials for drug delivery and other medical applications, namely polyesters and polyanhydrides. Biodegradable, photocrosslinked poly(ester anhydride) based on star-shaped poly(e-caprolactone) prepolymer (PEAH) has shown surface-erosion controlled drug release in vitro. In this study, PEAH was studied for sustained macromolecular drug delivery for the first time in vivo. Model compound was peptide YY3.36 (PYY3.36, Mw 3900 g/mol) which inhibits food intake. PYY3.36 loaded (1 % w/w) PEAH discoids were implanted (s.c.) to rats and plasma concentrations of PYY3.36 were analyzed.
机译：为了将两种良好表征的生物相容性材料，即聚酯和聚酸酐，结合起来，用于药物输送和其他医学应用，它们的聚醚酸酯已被开发出来。基于星形聚（ε-己内酯）预聚物（PEAH）的可生物降解的光交联聚（酯酐）已显示出体外表面侵蚀控制的药物释放。在这项研究中，首次对PEAH进行了体内大分子持续药物输送的研究。模型化合物是抑制食物摄入的肽YY3.36（PYY3.36，Mw 3900 g / mol）。将负载了PYY3.36（1％w / w）的PEAH圆盘植入（s.c.）大鼠，并分析了PYY3.36的血浆浓度。

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  • 来源
  • 会议地点 Tampere(FI);Tampere(FI)
  • 作者

    J. Monkare; R.A. Hakala; M. Kilpelainen; K.H. Herzig; H. Korhonen; et al;

  • 作者单位

    School of Pharmacy, Pharmaceutical Technology, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio,Finland;

    Laboratory of Polymer Technology, Department of Biotechnology and Chemical Technology, School of Science and Technology, Aalto University, P.O. Box 16100, FI-00076 Aalto, Finland;

    School of Pharmacy, Pharmaceutical Technology, University of Eastern Finland, P.O. Box 1627, FIN-70211 Kuopio,Finland Institute of Biomedicine and Biocenter of Oulu, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland;

    Institute of Biomedicine and Biocenter of Oulu, University of Oulu, P.O. Box 5000, FIN-90014 Oulu, Finland Department Psychiatry, Kuopio University Hospital, Box 1627, FIN-70211 Kuopio, Finland;

    Laboratory of Polymer Technology, Department of Biotechnology and Chemical Technology, School of Science and Technology, Aalto University, P.O. Box 16100, FI-00076 Aalto, Finland;

    et al;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 TB347;
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