Fibrinogen and growth factors binding on calcium phosphates and hybrids materials

摘要

Surface properties of materials are the key parameters in the interaction between an implanted device and the host tissue. Hydrophobicity or hydrophilicity of a material determines protein adsorption, platelet, cell and bacterial adhesion and biological activity. In a first approach, hydrophobic surfaces, tend to absorb proteins in a greater proportion than hydrophilic surfaces. Protein adhesion is the result of a competition between the hydrophobic effect and the dehydration of the surface. Proteins will only be adsorbed on a surface when the energy necessary for dehydrating the surface is lower than the energy required to expel the proteins from the solution to recover hydrogen bonds between water molecules otherwise separated by the proteins. However, some adsorption phenomena on hydrophilic surfaces have been reported which may not be easily dismissed. Some proteins such as fibrinogen possess both hydrophilic and hydrophobic domains and they can be adsorbed onto both types of surfaces. The desirable biological response to a surface depends largely on the specific applications and remains as an important target area of research in the preparation of biocompatible materials.