Simulation and Experimental Evaluation of Seed and Supersaturation Control Design Approaches for Crystallisation Processes

摘要

The paper presents a methodology for the systematic design of operating recipes forrnbatch cooling crystallisation systems with the aim to produce a desired target crystalrnsize distribution. The population balance model is solved using the method ofrncharacteristics under the assumptions of a constant supersaturation and growthrndominated process, yielding a simplified analytical expression for the size distribution.rnA method is proposed for designing the seed distribution, which can be used inrnconjunction with the supersaturation set-point design to shape the product crystal sizerndistribution (CSD). The approach designs the seed as a mixture of crystals obtainedrnfrom standard sieve analysis. A second approach is also proposed which uses dynamicrnseed addition during the batch to control the final size distribution.