Nano-sized asymmetric lipid vesicles for drug carrier applications

摘要

This paper describes a formation of asymmetric lipid vesicles with a size range of 100-400 nm in diameter, using an improved jetting method based on a microfluidic technology. When jet flow was applied to a planar lipid bilayer formed by a droplet contact method, nano-sized vesicles (100-400 nm in diameter) were found by a transmission electron microscopy (TEM). We also confirmed the generation of nano-sized asymmetric lipid vesicles by binding a gold colloid.