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首页> 外文会议>17th international conference on biomagnetism advances in biomagnetism - Biomag2010 >Magnetic Detection of the Sentinel Lymph Node in Ex Vivo Tissue with Colorectal Cancer
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Magnetic Detection of the Sentinel Lymph Node in Ex Vivo Tissue with Colorectal Cancer

机译：磁性检测结直肠癌离体组织中前哨淋巴结

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摘要

A new method for sentinel lymph node detection was investigated by ex-vivo experiments in colorectal cancer. A dispersion of superparamagnetic iron oxide (SPIO) nanoparti-cles was injected in the resected tissue around the tumor. A magnetic probe with a 2nd order gradiometer configuration was used to localize the sentinel lymph node with accumulated SPIO nanoparticles. Additional analysis of SPIO content was performed on the resected lymph nodes. High-field MR I and conventional microscopy revealed the presence and distribution of SPIO inside the lymph nodes. Magnetometry confirmed SPIO content in lymph nodes and could give an estimate of the amount of SPIO uptake.
机译：通过大肠癌的离体实验研究了一种检测前哨淋巴结的新方法。将超顺磁性氧化铁（SPIO）纳米颗粒的分散体注射到肿瘤周围切除的组织中。使用具有二阶梯度仪配置的磁性探针定位具有积累的SPIO纳米粒子的前哨淋巴结。对切​​除的淋巴结进行了SPIO含量的进一步分析。高视野MR I和常规显微镜检查显示了SPIO在淋巴结内的存在和分布。磁力计证实了SPIO在淋巴结中的含量，可以估计SPIO摄入量。

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  • 来源
  • 会议地点 Dubrovnik(HR);Dubrovnik(HR)
  • 作者

    B. ten Haken; M. Visscher; J.J. Pouw; J.M. Klaase; Q.A. Pankhurst; J. Galindo-Millan; A.H. Velders; H. Rogalla;

  • 作者单位

    University of Twente, MIRA Institute for biomedical technology and technical medicine, Department of Low Temperatures - Biomagnetism, Enschede, The Netherlands;

    University of Twente, MIRA Institute for biomedical technology and technical medicine, Department of Low Temperatures - Biomagnetism, Enschede, The Netherlands;

    Medisch Spectrum Twente, Department of Surgery, Enschede, The Netherlands;

    Medisch Spectrum Twente, Department of Surgery, Enschede, The Netherlands;

    The Royal Institution of Great Britain, Davy-Faraday Research Laboratory, London, UK;

    University of Twente, MESA+ Institute for nanotechnology, Department of Supramolecular Chemistry and Technology, Enschede, The Netherlands;

    University of Twente, MESA+ Institute for nanotechnology, Department of Supramolecular Chemistry and Technology, Enschede, The Netherlands;

    University of Twente, MIRA Institute for biomedical technology and technical medicine, Department of Low Temperatures - Biomagnetism, Enschede, The Netherlands;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 生物工程学（生物技术）;
  • 关键词

    sentinel lymph node; superparamagnetic iron oxides; magnetometry; mri;

    机译：前哨淋巴结;超顺磁性氧化铁；磁力计磁共振;

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