Toward a Molecular and Synaptic Understanding of Chronic Pain

摘要

In conclusion，cumulative evidence consistently suggest that genetic mouse models ca-n help us to understand neurobiological basis of brain cognition andmental disease,and have generated new and novel information regarding the basic mechanisms ofchroni-c pain，particularly at the cortical levels. It is clear that injuries trigger a se-ries of plasticchanges in pain-related cortical areas including the ACC.Chronic pain also triggers a series of brain disorders such as emotional fear，anxiety，mood de-pression，and impairment of cognitivefunctions. Future studies designed to understa-nd the relationship between pain and mood disorders,and identify novel molecular targets contributing to these events，will help us to find better pain medicine.