METHOD FOR PREPARING NOVEL CORONAVIRUS VACCINE AND METHOD FOR EVALUATING EFFECTIVENESS THEREOF

摘要

Provided in the present invention are a method for preparing a novel coronavirus vaccine and a method for evaluating the effectiveness thereof. The novel coronavirus vaccine is an inactivated vaccine in which a part of a virus membrane is split so as to expose a nucleocapsid N antigen. The vaccine strain is inactivated twice during preparation, the first inactivation is carried out by means of using formaldehyde (HCHO), and then the second inactivation is carried out by means of using β-propiolactone (BPL). The method for evaluating the novel coronavirus vaccine comprises a plurality of detection methods comprising antibody neutralization, Elisa antibody determination and specific CTL detection.