NANO CO-DELIVERY OF QUERCETIN AND ALANTOLACTONE PROMOTES ANTI-TUMOR RESPONSE THROUGH SYNERGISTIC IMMUNOGENIC CELL DEATH FOR MICROSATELLITE-STABLE COLORECTAL CANCER

摘要

Disclosed are micellar formulations comprising a synergistic combination of quercetin and alantolactone and their use for treating a cancer, including microsatellite-stable colorectal cancer (CRC), which otherwise is resistant to immunotherapy. The combination of quercetin and alantolactone was found to induce synergistic immunogenic cell death (ICD) at synergistic ratiometric micellar loadings.