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Compositions and Methods for Producing Antibodies Based on the Use of Expression-Enhanced loci
Compositions and Methods for Producing Antibodies Based on the Use of Expression-Enhanced loci
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机译:成分和产生抗体的方法基于Expression-Enhanced位点的使用
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摘要
This invention relates to site-specific integration and expression of recombinant proteins in eukaryotic cells. In particular, the invention includes compositions and methods for improved expression of antigen-binding proteins including monospecific and bispecifc antibodies in eukaryotic cells, particularly Chinese hamster (Cricetulus griseus) cell lines, by employing multiple expression-enhancing locus.
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