Antidepressants for the Treatment or Prevention of Memory Loss and/or Cognitive Decline or Dysfunction in Aging

摘要

The present invention includes a method of treating or preventing memory loss in a subject suffering from a memory loss-related disease or aging, comprising, consisting essentially of, or consisting of, administering an effective amount of a serotonin-norepinephrine reuptake inhibitor (SNRI) to the subject, wherein the serotonin-norepinephrine reuptake inhibitor is duloxetine or active derivative thereof, such as a subject with memory complaints as part of the aging process, mild cognitive impairment, Alzheimer's disease or dementia and an elevated depressive endophenotype genotype (DepE).