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Uses of epithelial-to-mesenchymal inhibitors in generating pacemaker cells
Uses of epithelial-to-mesenchymal inhibitors in generating pacemaker cells
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机译:epithelial-to-mesenchymal抑制剂的使用生成起搏细胞
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摘要
This disclosure relates to methods of generating pacemaker cells for use in therapeutic strategies that address a heart that beats abnormally. In certain embodiments, one mixes cells with an epithelial-to-mesenchymal transformation inhibitor in combination with a nucleic acid encoding a transcription factor such as a vector that encodes a transcription factor such as Tbx18 in operable combination with a eukaryotic promoter to produce pacemaker cells that are then transplanted into the heart.
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