Use of hepatic progenitor or stem cells, their lysates and/or conditioned media in disorders characterized by vascular permeability

摘要

The present invention provides hepatic progenitor cells for use in the treatment of diseases and/or conditions due to increased vascular permeability, or for use in restoring the vascular integrity of cells and tissues of a subject following inflammation and/or infection in a subject. or stem cells, a lysate thereof, and/or a conditioned medium obtainable by culturing the liver progenitor cells or stem cells in the medium. More specifically, the present invention relates to a medium for hepatic progenitor cells or stem cells, or hepatic progenitor cells or stem cells, for therapeutic use in sepsis and sepsis-causing diseases such as myocardial edema, acute kidney injury and pulmonary sepsis. It relates to a conditioned medium obtainable by culturing in