PROBLEM TO BE SOLVED: To provide an M protein (including a fragment, a variety, or a derivative thereof) of a group A linked bacterium, or an antibody which binds to or is produced against the M protein, and, if necessary, A. By administering a group-linked bacterium superantigen protein (including a fragment, a variety, or a derivative thereof), or an antibody or antibody fragment produced by binding to or produced against the superantigen protein in a subject. Provide methods for immunizing, treating, or preventing sexual shock syndrome. [Selection diagram] FIG. 13
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