PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS IN DIABETES AND POSTMENOPAUSE CONTAINING ADIPORON

摘要

The present invention relates to a pharmaceutical composition for preventing or treating diabetic and postmenopausal osteoporosis comprising adiporone. The composition of the present invention controls bone-related factors through activation of the adiponectin-receptor 1-AMPK-Nrf2 signaling system and the adiponectin-receptor 2/PPARα-PGC-1α signaling system in bone tissue, improves lipotoxicity, and has a growth plate promoting effect and growth plate Through the chondrocyte proliferation effect, it can be usefully used as a therapeutic agent for diabetes mellitus and postmenopausal osteoporosis.