CONSTRUCTION FOR PP2 OBLIGATE ANAEROBIC SALMONELLA STRAIN AND APPLICATION OF SAME IN TUMOR TREATMENT

摘要

Provided are a PP2 gene sequence of an anaerobic activation promoter, an anaerobic gene loop regulated by a PP2 promoter, obligate anaerobic Salmonella typhimurium containing the anaerobic gene loop regulated by the PP2 promoter, a vector, and an application of the obligate anaerobic Salmonella typhimurium in tumor treatment. Also provided are a method for changing facultative anaerobic bacteria into obligate anaerobic bacteria, a method for treating cancers using anaerobic loop-regulated bacteria, and an application of the methods in tumor treatment.