ALL-TRANS RETINOIC ACID LIPOSOME PREPARATION, AND PREPARATION AND APPLICATION THEREOF

摘要

The present disclosure relates to an all-trans retinoic acid liposome formulation and a preparation method thereof. The all-trans retinoic acid liposome formulation includes all-trans retinoic acid and a liposome vector. The disclosure adopts an active drug loading method, including a calcium acetate gradient method or a sodium acetate gradient method. The prepared all-trans retinoic acid formulation has high drug loading and high stability in vivo, thereby increasing the blood concentration and prolonging the half-life of the all-trans retinoic acid.