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ALL-TRANS RETINOIC ACID LIPOSOME PREPARATION, AND PREPARATION AND APPLICATION THEREOF

机译：全反式视黄酸脂质体的制备及其制备和应用

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An all-trans retinoic acid liposome preparation, and preparation and application thereof. The all-trans retinoic acid liposome preparation comprises an all-trans retinoic acid and a liposome carrier. The preparation method adopts an active drug loading method, comprising a calcium acetate gradient method or a sodium acetate gradient method. The all-trans retinoic acid preparation prepared has high drug loading and high in vivo stability, thereby improving the plasma concentration and extending the half-life of the all-trans retinoic acid. 展开▼

机译：全反式视黄酸脂质体制剂及其制备和应用。全反式视黄酸脂质体制剂包含全反式视黄酸和脂质体载体。制备方法采用活性药物负载法，包括乙酸钙梯度法或乙酸钠梯度法。制备的全反式视黄酸制剂具有较高的载药量和较高的体内稳定性，从而提高了血浆浓度并延长了全反式的寿命。反式视黄酸。展开▼

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公开/公告号WO2018033118A1

专利类型

公开/公告日2018-02-22

原文格式PDF

申请/专利权人 SHANGHAI JIAO TONG UNIVERSITY;
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申请/专利号WO2017CN97869

发明设计人 XU YUHONG;ZHENG ANJIE;CHEN XIAOLONG;
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申请日2017-08-17

分类号A61K9/127;A61K31/203;A61K47/40;A61K47/34;A61K47/32;A61K47/38;A61P35;

国家 WO

入库时间 2022-08-21 12:45:41

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