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FAB Molecules with a Rodent Hinge Region and a Non-Rodent CH1 Region
FAB Molecules with a Rodent Hinge Region and a Non-Rodent CH1 Region
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机译:具有啮齿动物铰链区和非啮齿动物CH1区的FAB分子
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摘要
The disclosure relates to novel Fab molecules comprising a modified heavy chain constant region. The modified constant region prevents the recognition of the Fab molecules by anti-Fab antibodies present in a host's serum. The disclosure further relates to methods of generating such modified Fab molecules for biological, diagnostic, pharmaceutical and other uses.
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