COMPOSITION FOR PREVENTION, AMELIORATION OR TREATMENT OF POOR OVARIAN RESPONDERS CAUSED BY AGING, COMPRISING MIXED MEDICINAL HERB EXTRACT AS ACTIVE INGREDIENT

摘要

The present invention relates to a composition for the prevention, amelioration or treatment of poor ovarian responders caused by aging, comprising, as an active ingredient, a mixed medicinal herb extract consisting of Rehmannia glutinosa var. purpurea, Paeonia lactiflora, Cnidium officinale, and Angelica gigas, and statistically significant increases in the number of antral follicles and the number and quality of mature oocytes were confirmed in 40-week-old mice corresponding to humans of 40 years old or older, to which the mixed medicinal herb extract was orally administered. In women, the number of primordial follicles in the ovary continues to decrease with aging, and moreover, the number of antral follicles, which is the stage right before ovulation, decreases. As a result, the number of ovulating healthy mature oocytes (MII oocytes) decreases, thus gradually reducing the possibility of pregnancy. The mixed medicinal herb extract of the present invention can improve the number of antral follicles and the number and quality of mature oocytes, and thus has the effect of increasing the chance of getting pregnant in older women.