USE OF STATINS IN OVERCOMING RESISTANCE TO BETA-LACTAM ANTIBIOTICS IN BACTERIAL SPECIES SYNTHETIZING ISOPRENOIDS USING THE MEVALONATE SYNTHETIC PATHWAY

摘要

The present invention relates to a beta-lactam antibiotic for use in a method of treating a bacterial infection in a subject in need thereof wherein said bacterial infection is caused by a bacterial species characterized by using the mevalonate synthetic pathway, wherein said subject is further treated, before or simultaneously to said beta-lactam antibiotic, with a statin, wherein said statin is for use in reducing, mitigating or reversing resistance to said beta-lactam antibiotic in resistant bacterial populations of said bacterial species.