disease onset information generating apparatus based on time-dependent correlation using polygenic risk score and method therefor

摘要

The present invention relates to a technology for generating disease onset information based on time-dependent association using a multigene risk score, and a plurality of groups classified using pre-processed genomic data and screening result data in generating disease onset information including onset prediction information Individual screening for each disease-related factor included in the screening result data in a time-dependent correlation calculation model in which a PRS model was designed for each group for a plurality of genetic mutations included in the PRS model, and the multigene risk score calculated using the PRS model was applied as a covariate. By inputting the result values, the correlation size for each time point between the independent variable and the dependent variable to be input to the COX model is calculated, selected as a time series characteristic variable, and the at least one time series characteristic variable calculated for the examination result data is applied and applied By performing COX regression analysis for each group on the examination result data on the disease-related factors of the personnel of The purpose is to provide relatively more accurate disease onset information by reflecting it.