SIMULTANEOUS FOCUSED ULTRASOUND AND FMRI AND APPLICATION OF FOCUSED ULTRASOUND OUTSIDE OF MRI ENVIRONMENT

摘要

A workflow has been developed that enables initially mapping of a focused ultrasound (FUS) beam using magnetic resonance (MR) thermometry or MR-acoustic radiation force imaging (MR-ARFI) while working within the MRI device. During this procedure, key measurements will be taken including the precise location of the transducer relative to the skull and the transducer parameters (such as amplitudes and phases) required to place the ultrasound focus at the desired focal size and location in the skull. The anatomical measurements will be used to build a patient-specific, device-specific stereotactic frame to hold the transducer in the position relative to the skull and the aberration corrects will be applied. FUS therapy can then be delivered to the patient outside of the MR environment.