New combination of tubulin polymerization inhibitor and poly (ADP-ribose) polymerase (PARP) inhibitor for use in the treatment of cancer

摘要

PROBLEM TO BE SOLVED: To provide a novel combination of a tubulin polymerization inhibitor and a poly (ADP-ribose) polymerase (PARP) inhibitor for use in the treatment of cancer. SOLUTION: A tubulin polymerization inhibitor such as a compound of formula I or a pharmaceutically acceptable salt thereof is used, and a poly (ADP-ribose) polymerase (PARP) inhibitor or a pharmaceutically acceptable salt thereof is used. Thus, methods and combination therapies for treating and preventing cancer and / or delaying the onset and / or development of cancer are provided. [Selection diagram] None