SENSITIVITY ADVANCES IN ULTRASOUND SWITCHABLE FLUORESCENCE SYSTEMS AND TECHNIQUES

摘要

In one aspect, ultrasound-switchable fluorescence (USF) imaging systems are described herein. In some embodiments, such a system comprises an ultrasound source, a fluorophore excitation source, a contrast agent comprising a fluorophore, and an image recording device. The contrast agent, in some cases, comprises a fluorophore associated with a liposome carrier, wherein the contrast agent has a size of up to 1 μm. Further, in some implementations of a system described herein, the image recording device is controlled by a software trigger mode.