A transgenic mouse model that supports innate immune function

摘要

In some aspects, NOD. Contains nucleic acids encoding human FLT3L and the inactivated mouse Flt3 allele. Cg-Prkdc scid Il2rg tm1Wjl / SzJ (NOD scid gamma or NSG TM ) mice, methods of producing the above mice, and methods of using the above mice are provided herein. NOD. A Cg-Prkdc scid Il2rg tm1Wjl / SzJ (NOD scid gamma) mouse, wherein the mouse contains a nucleic acid encoding human FLT3L and an inactivated mouse Flt3 allele.