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Human Genomic Construct Reporter Cells and Mouse Models to Screen Therapeutics against Microglia-expressed Disease Associated Genes

机译：人类基因组构建报告细胞和小鼠模型，以筛选针对小胶质细胞表达的疾病相关基因的治疗方法

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摘要

The present invention relates to microglial or myeloid expressed Alzheimer's disease associated (ME-AD) gene reporter constructs, cell lines and transgenic animals and their use for identifying agents that modulate the level or expression of ME-AD genes.

机译：本发明涉及小胶质细胞或髓系表达的阿尔茨海默病相关（ME-AD）基因报告构建体、细胞系和转基因动物及其用于识别调节ME-AD基因水平或表达的试剂的用途。

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公开/公告号US2022099659A1

专利类型
公开/公告日2022-03-31

原文格式PDF
申请/专利权人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;
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申请/专利号US202017425580
发明设计人 XIANGDONG WILLIAM YANG;XIAOFENG GU;
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申请日2020-01-22
分类号G01N33/50;A01K67/027;
国家 US
入库时间 2022-08-25 00:11:26

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