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TECHNIQUES FOR SYSTEM SUITABILITY TESTING OF INERT LIQUID CHROMATOGRAPHY SYSTEMS AND COLUMNS
TECHNIQUES FOR SYSTEM SUITABILITY TESTING OF INERT LIQUID CHROMATOGRAPHY SYSTEMS AND COLUMNS
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机译:惰性液相色谱系统和色谱柱的系统适用性测试技术
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摘要
The present disclosure is directed to methods of characterizing a system containing a chromatographic column. The methods can include introducing a sample comprising a positive control and a negative control to the system containing a chromatographic column, wherein the positive control is a sensitive probe that interacts with the system and the negative control is substantially non-interacting with the system; after passing the sample through the chromatographic column, detecting the positive control and the negative control; and determining system suitability by comparing the amount of detected positive control to negative control. In some embodiments, determining system suitability (e.g., inertness of sample to the system) is accomplished by determining a ratio of detected positive control to negative control.
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