Clonidine and/or clonidine derivatives for use in the prevention and/or treatment of adverse side effects of chemotherapy

摘要

The present invention relates to certain clonidine and/or clonidine derivatives for use in the prevention and/or treatment of adverse side effects of alkylating agent chemotherapy, other than those resulting from mucosal inflammation. The present invention also relates to the use of the present clonidine and/or clonidine derivatives for the manufacture of a pharmaceutical composition for the purpose of preventing and/or alleviating the adverse side effects of alkylating agent chemotherapy, other than those resulting from mucosal inflammation. The present invention also relates to a kit comprising (a) clonidine and/or clonidine derivatives and (b) at least one alkylated chemotherapeutic agent as a combination preparation for simultaneous, separate or sequential use in the treatment of cancer.