clonidine and / or clonidine derivatives for use in the prevention and / or treatment of chemotherapy adverse side effects

摘要

The present invention relates to clonidine and / or specific clonidine derivatives for use in the prevention and / or treatment of adverse chemotherapy side effects of alkylating agents other than those resulting from mucosal inflammation. It also relates to the use of this clonidine and / or clonidine derivative for the manufacture of a pharmaceutical composition intended to prevent and / or alleviate the adverse side effects of chemotherapy of alkylating agents, other than those resulting from mucosal inflammation. This invention is further directed to a kit comprising: (a) a clonidine and / or a clonidine derivative, and (b) at least one chemotherapeutic alkylating agent as a combined preparation for simultaneous, separate or sequential use in the treatment of cancer. .