ATOPIC DERMATITIS ANIMAL DESEASE MODEL PRODUCING METHOD USING MEDIUM AND LARGE ANIMALS AND ATOPIC DERMATITIS ANIMAL DESEASE MODEL OF MEDIUM AND LARGE ANIMALS PRODUCED THEREOF

摘要

The present invention relates to a method for manufacturing an atopic dermatitis disease model using a large animal, and to a large animal atopic dermatitis disease model manufactured by the method. Specifically, after sensitization of house dust mites according to the present invention, large animals exposed to the house dust mite environment showed clinical symptoms of atopic dermatitis, inflammatory cells and skin edema significantly increased, and the production of allergen-specific IgE antibody in the serum By increasing significantly, it can be usefully used as a disease model for atopic dermatitis in medium-sized animals.