ATOPIC DERMATITIS ANIMAL MODELS FOR HUMAN DISEASES AND A METHOD FOR PRODUCING THE SAME, CAPABLE OF BEING WIDELY USED FOR ANALYZING THE CAUSES OF ATOPIC DERMATITIS AND DEVELOPING A MEDICINE

摘要

PURPOSE: Atopic dermatitis animal models for human diseases and a method for producing the same are provided to be effectively used for analyzing the causes of atopic dermatitis and developing a medicine for the atopic dermatitis.;CONSTITUTION: A method for producing atopic dermatitis animal models for human diseases comprises the following steps: increasing a blood immunoglobulin E concentration of an experimental animal to 800ng/ml or more by removing hairs form the skin of the experimental animal and spreading an immunity disturbance substance; and spreading atopic inducers on the skin of the experimental animal. The immunity disturbance substance is TMA(trimellitic anhydride) or DNCB(1-chloro-2, 4 dinitrobenzene).;COPYRIGHT KIPO 2011