A multi-target fusion protein that blocks the proliferation of vascular endothelial cells and activates T cells, and pharmaceutical compositions containing them.

摘要

The present invention blocks the proliferation of vascular endothelial cells and activates T cells, including the vascular endothelial growth inhibitor domain (i), immunoglobulin Fc domain (ii), and CD80 extracellular domain (ECD) (iii). Provides a multi-target fusion protein. The present invention comprises a polynucleotide encoding the multi-target fusion protein, a vector containing the polynucleotide, a host cell containing the polynucleotide or vector, and a pharmaceutical composition comprising the multi-target fusion protein and an anti-PD-1 antibody. We are offering more things. The multi-target fusion protein and pharmaceutical composition of the present invention can treat or prevent a cancerous disease in an individual. [Selection diagram] FIG. 4