Methods and Compositions for Treating Non-ERK MAPK Path Inhibitor Resistant Cancers

摘要

PROBLEM TO BE SOLVED: To provide a method and a composition for treating a cancer resistant to a non-ERK MAPK pathway inhibitor. The present invention, among other things, methods, pharmaceutical compositions and pharmaceutical compositions for treating or ameliorating the effects of cancers that are refractory or resistant to non-ERK MAPK pathway inhibitor therapy, among others. Provide a kit. Methods for identifying cancer subjects that may benefit from ERK inhibitor therapy, and inhibiting phosphorylation of RSK in cancer cells that are refractory or resistant to non-ERK MAPK pathway inhibitors. A method for is also provided. The method comprises administering to the subject an effective amount of BVD-523 or a pharmaceutically acceptable salt thereof. [Selection diagram] None