Compositions used as prophylaxis for people at risk of TB infection or as a secondary drug to treat infected TB patients

摘要

The present invention is characterized by comprising a PhoP-phenotype due to inactivation by a genetic deletion of the Rv0757 gene and a deletion (PDIM-phenotype) of a second gene Rv2930 (fadD26) that interferes with PDIM production. Mycobacterium tuberculosis complex, preferably M. Tubercrosis clinical isolate, more preferably M. The present invention relates to a freeze-dried composition comprising an isolated microorganism belonging to a tuberculosis clinical isolate (MTBVAC strain) and sucrose and monosodium glutamate as stabilizers or excipients. Further, the present invention, along with the reconstituted composition obtained by adding water, preferably sterile water for injection, to the freeze-dried composition, in particular, M. et al. With respect to their use as a prophylactic agent for those at risk of contracting tuberculosis or at risk of developing tuberculosis disease, or as a secondary drug for treating infected tuberculosis patients. [Selection diagram] None