CHIMERIC ANTIGEN RECEPTOR USED FOR CLEARANCE OF PATHOLOGIC PROTEIN AGGREGATES AND APPLICATION THEREOF

摘要

Provided in the present invention is a pathogen-targeted chimeric antigen receptor (CAR) polypeptide used for the clearance of pathological protein aggregates, having: (a) an extracellular domain comprising one or more pathological protein aggregate-specific antigen-binding regions; (b) a transmembrane domain; and (c) at least one copy of the intracellular signal domain of a phagocytic cell-specific phagocytic signal receptor. The present invention further provides a polynucleotide encoding the polypeptide, a gene vector, a recombinant cell carrying the chimeric antigen receptor used for the clearance of pathological protein aggregates, and a composition. In the pathogen-targeted chimeric antigen receptor polypeptide used for the clearance of pathological protein aggregates provided in the present invention, the extracellular domain can specifically identify pathological protein aggregates, and the intracellular signal domain can activate and mediate cell phagocytosis to clear the pathological protein aggregates; the process does not mediate cytokine release, antigen presentation, or tissue damage.