Nucleic acid encoding chimeric antigen receptor protein and T lymphocyte expressing chimeric antigen receptor protein

摘要

PROBLEM TO BE SOLVED: To provide a treatment with a recombinant T lymphocyte for a tumor of epithelial origin that expresses EGFRvIII or highly expresses EGFR. A nucleic acid encoding a chimeric antigen receptor protein expressed on the surface of human T cells, wherein the chimeric antigen receptor protein comprises an extracellular binding region, a transmembrane region and an intracellular signal region which are sequentially linked. Wherein the extracellular binding region specifically comprises a single chain antibody scFv(EGFR) which specifically identifies the 287-302 amino acid epitope of human epidermal growth factor receptor EGFR. [Selection diagram] Figure 1