Nucleic acid encoding chimeric antigen receptor protein and T lymphocyte expressing chimeric antigen receptor protein

摘要

A nucleic acid encoding a chimeric antigen receptor protein expressed on the surface of a human T cell, the chimeric antigen receptor protein comprising an extracellular binding region, a transmembrane region and an intracellular signal region linked in sequence, The nucleic acid comprising the single-chain antibody scFv (EGFR), wherein the extracellular binding region specifically identifies the amino acid epitope at positions 287-302 of human epidermal growth factor receptor EGFR.