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FORMULATION OF ARRAYS OF PLAN FREE CRYPT WITH A COMPARTMENT OF STEM CELLS/PROLIFERATIVE CELLS AND A DIFFERENCED CELL ZONE
FORMULATION OF ARRAYS OF PLAN FREE CRYPT WITH A COMPARTMENT OF STEM CELLS/PROLIFERATIVE CELLS AND A DIFFERENCED CELL ZONE
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机译:具有干细胞/增殖细胞隔室和差异化细胞区的无计划隐窝阵列的形成
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摘要
A method for producing tissue constructs comprising two or more distinct regions, each of which comprises a different cell population or lineage is described. The method involves providing a support substrate or substrate assembly comprising two or more physically distinct regions, wherein the two or more physically distinct regions of the support substrate or substrate assembly are different from each other; and depositing/positioning one or more cells on the support substrate or substrate assembly. The cells can form a continuous monolayer with at least two zones, e.g., a proliferative zone and a nonproliferative zone, that can act as in vitro intestinal models. The models are two-dimensional, thus facilitating rapid and facile imaging. Systems comprising the tissue constructs and methods of using the constructs to study the effects of pharmaceuticals, uutraceuticais, and metabolites on intestinal cells are also described.
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