METHOD OF DETERMINING LONG-TERM SURVIVAL OF CANCER PATIENTS WITH OVARIAN CANCER

摘要

The invention relates to in vitro methods for predicting tumour progression or response to anticancer therapy of a cancer patient the method comprising the steps of: 1) providing engineered mammalian immune cells comprising: - a NFkB signalling reporter construct and an IFN signalling reporter construct, 2) contacting the engineered cells with a blood sample of a cancer patient, allowing induction of the NFkB and/or IFN signalling pathways of said engineered cells by the blood sample, 3) determining the expression and/or activity levels of the first and second reporter protein, 4) comparing the expression levels and/or activity of the first and second reporter protein determined in step 3) with the expression and/or activity levels of the first and second reporter protein in a reference sample of a healthy individual, 5) based on the comparison predicting tumour progression, or response to anticancer therapy of the cancer patient.