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NEW TRIAZOLE AND TRIAZOLOTHIADIAZINE DERIVATIVES EXERTING CYTOTOXIC AND APOPTOTIC EFFECTS ON A549 CELLS THROUGH AKT INHIBITION
NEW TRIAZOLE AND TRIAZOLOTHIADIAZINE DERIVATIVES EXERTING CYTOTOXIC AND APOPTOTIC EFFECTS ON A549 CELLS THROUGH AKT INHIBITION
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机译:通过AKT抑制施加细胞毒性和三唑噻嗪衍生物对A549细胞的细胞毒性和凋亡作用
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摘要
The invention is related to new 1,2,4-triazolo[3,4-b]-1,3,4-thiadiazine (2a-j) and 7 new 1,2,4-triazole (3a-g) derivatives and synthesis of these compounds, in vitro anticancer activity studies and molecular docking and insilico ADME studies. It was determined that compounds 2c, 2d, 3b, 3d and 3g of the invention exert their cytotoxic and apoptotic effects on A549 human lung adenocarcinoma cell line through Akt inhibition.
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