Pyridine and pyrazine derivatives for the treatment of CF, COPD, and bronchiectasis

摘要

The present invention is for treating bronchiectasis, cystic fibrosis, primary ciliary dyskinesia, chronic bronchitis, chronic obstructive pulmonary disease, asthma, airway infection, lung cancer, dry mouth and keratoconjunctivitis or constipation (IBS, IBD, opioid-induced) Provided are pyridine and pyrazine derivatives that restore or enhance the function of mutant and/or wild-type CFTR. Pharmaceutical compositions comprising such derivatives are also included.