Stem cell having improved hypoxia adaptation and therapeutic potential by induction of BICD1 expression and method for preparing the same, and cell therapeutic composition comprising the same

摘要

The present invention relates to stem cells with improved ischemic adaptation ability and therapeutic function through increased expression of BICD1 (Bicaudal D homolog 1); Cell therapy composition for the prevention or treatment of ischemic diseases, containing the stem cells or cells differentiated from the mesenchymal stem cells as an active ingredient; And it relates to a method for producing stem cells with improved therapeutic function in hypoxic conditions, characterized in that it comprises the step of increasing the expression of BICD1. It is significant in that it suggests a new approach to control ischemic adaptation, and it can significantly increase the effectiveness of mesenchymal stem cells in therapeutic application, and will be widely used in fields such as medicine, pharmaceuticals, and veterinary medicine. can