TARGETED DRUG DELIVERY SYSTEM TO BE USED IN TREATING OSTEOMYELITIS

摘要

A targeted drug delivery system to be used in treating osteomyelitis is provided. Gelatin nanoparticles suitable for a drug release in treating the osteomyelitis includes magnetite and antibiotics, wherein the antibiotics are gentamicin. A production method of the gelatin nanoparticles includes the steps of: dissolving collagen, enabling a precipitation of gelatin having a large mass of molecule, removing the gelatin having a small sized molecule mass, re-dissolving the gelatin with the large mass of the molecule in water and adjusting a pH of the gelatin to 10-13 with a NaOH solution after the dissolving is completed, adding 2-6 mg/ml magnetite dispersion, adding acetone dropwise, adding 0.02-0.2 ml 5-9 mg/ml genipin as a cross linker, and adding 3.5-7 mg/ml 0.1-1 ml antibiotics on magnetic gelatin nanoparticles.