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METHOD FOR SCREENING OF UNPLEASANT ODOR MASKING AGENTS
METHOD FOR SCREENING OF UNPLEASANT ODOR MASKING AGENTS
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机译:筛选令人不快的气味掩蔽剂的方法
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摘要
The present invention relates to a method for screening a candidate substance for an unpleasant odor masking agent from among test substances using an olfactory receptor that is responsive to an unpleasant odor-causing substance. The screening method of the present invention includes the steps of:adding a test substance and an unpleasant odor-causing substance to an olfactory receptor polypeptide selected from the group consisting of OR2L3 and polypeptides which comprise an amino acid sequence having at least 80% identity to an amino acid sequence of OR2L3 and are responsive to the unpleasant odor-causing substance;measuring a response of the olfactory receptor polypeptide to the unpleasant odor-causing substance; andidentifying the test substance that suppresses the response of the olfactory receptor polypeptide as a candidate substance for the unpleasant odor masking agent based on the measured response.
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机译:本发明涉及使用嗅觉引起的令人抑制的气味物质的嗅觉受体筛选来自试验物质中的候选物质的候选物质的方法。 本发明的筛选方法包括以下步骤:将测试物质和令人不快的气味物质添加到选自的嗅觉受体多肽中,所述嗅觉受体多肽选自组成的组成的组,所述多肽,所述多肽包含至少80%同一性的氨基酸序列 OR 2L3的氨基酸序列,并响应于令人不愉快的气味物质;测量嗅觉受体多肽对令人不愉快的气味物质的响应; 并凝结抑制嗅觉受体多肽作为候选物质的响应的测试物质,基于测量的反应抑制令人难倒的气味掩蔽剂的候选物质。
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